Dna thesis

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Essay on dna structure and replication for essay on population of india 2011

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DNA is a macromolecule made up of nucleotide units, which are linked by covalent bonds and hydrogen bonds, in a repeating structure. DNA synthesis occurs when these nucelotide units are joined together to form DNA; this can occur artificially in vitro or naturally in vivo. Nucleotide units are made up of a nitrogenous base cytosine, guanine, adenine or thymine , pentose sugar deoxyribose and phosphate group. Each unit is joined when a covalent bond forms between its phosphate group and the pentose sugar of the next nucleotide, forming a sugar-phosphate backbone. DNA is a complementary, double stranded structure as specific base pairing adenine and thymine, guanine and cytosine occurs naturally when hydrogen bonds form between the nucleotide bases. Though each type of synthesis is very different, they do share some features. DNA replication also works by using a DNA template, the DNA double helix unwinds during replication, exposing unpaired bases for new nucleotides to hydrogen bond to.
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Ribosomes are large, multi-subunit ribonucleoprotein complexes, essential for protein synthesis. In all eukaryotes studied, rDNA genes are arranged in one or more clusters of tandem repeats localized to nucleoli. The tandem arrangement of repeats, combined with the high rates of transcription at the rDNA loci, and the difficulty of replicating repetitive sequences make the rDNA inherently unstable and particularly susceptible to large variations in repeat copy number. Despite mounting evidence suggesting extra-ribosomal functions of the rDNA, its repetitive nature has excluded it from traditional sequencing-based studies. However, more recently, several studies have revealed the unique potential of the rDNA to act as a "canary in the coalmine," being particularly sensitive to genomic stresses and acting as a source of adaptive response.
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