A more recent article on genital herpes is available. JOHN G. Army Hospital, Fort Carson, Colorado. Patient information: See related handout on genital herpes , written by the author of this article. Genital herpes simplex virus infection is a recurrent, lifelong disease with no cure. The natural history includes first-episode mucocutaneous infection, establishment of latency in the dorsal root ganglion, and subsequent reactivation.
Hsv hesi case study quizlet
Case study: inoculation herpes barbae
Herpes simplex virus HSV infection is a common cause of ulcerative mucocutaneous disease in both immunocompetent and immunocompromised individuals. However, both oral infection with HSV-2 and particularly genital infection with HSV-1 are increasingly recognized, likely as a result of oral-genital sexual practices. The clinical presentations of the 2 virus types are indistinguishable. The hallmarks of HSV infection are periodic symptomatic reactivation and asymptomatic viral shedding. Infection with HSV is a lifelong condition; the virus becomes permanently latent in the nerve root ganglia corresponding to the site of inoculation the trigeminal ganglia for orolabial infection and the sacral ganglia for genital infection. HSV induces antibody and cell-mediated immune responses that modulate the severity of recurrent disease, but these are insufficient to eradicate infection. In immunocompromised individuals, such as those with HIV-1 infection, impaired immunity leads to more frequent and severe symptomatic and asymptomatic HSV reactivation.
Herpes Simplex Virus (HSV)
Diego Villa, Brian Skinnider; Herpes simplex virus lymphadenitis. Blood ; 1 : A year-old man with relapsed chronic lymphocytic leukemia with deletion of chromosome 11q initiated second-line treatment with bendamustine and rituximab. Physical examination revealed peripheral lymphadenopathy and a herpes simplex virus HSV —like lesion in the right perioral region. After the first cycle, there was rapid improvement in blood counts and lymphadenopathy.
A year-old white man in otherwise excellent general health was referred for a painful, progressive, facial eruption with associated fever, malaise, and cervicofacial lymphadenopathy. The patient reported that a vesicular eruption progressed from the left side of his face to also involve the right side of his face over the 48 hours preceding his clinic visit. He also reported some lesions in his throat and the back of his mouth causing pain and difficulty swallowing. Four to 7 days before presentation to us, the patient noted exposure to his girlfriend's cold sore.